Multidimensional Engineering Delivers a High-Performance C11α-Steroid Hydroxylase for Practical Application
resulted in 10.6 g/L in flask and 24.8 g/L in high-cell density bioreactor. This study establishes a versatile, sustainable, and scalable biocatalytic route for steroid functionalization.
Authors
- Chenghua Gao
- Lingrui Wei
- 郭志勇
- Y LI
- Aitao Li (ORCID: https://orcid.org/0000-0001-6036-4058)
- Pan Xiao (ORCID: https://orcid.org/0009-0005-3319-0431)
- Jiahui Wu
- Ling Wang
- Qian Li
Institutions
- Hubei University (CN)
Publication Details
- Journal
- Journal of Agricultural and Food Chemistry
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1021/acs.jafc.5c17759
- Primary Topic
- Steroid Chemistry and Biochemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- State Key Laboratory of Biocatalysis and Enzyme Engineering
- National Key Research and Development Program of China