Bacterial factors required for biofilm formation in Staphylococcus epidermidis are linked to contact activation
-induced activation of contact factors. In plasma, HKH20 decreased the formation and size of bacterial aggregates and altered biofilm architecture by modulating fibrin network formation. Together, these findings identify extracellular DNA and PIA as biofilm-relevant bacterial factors that are linked to contact system activation and intrinsic coagulation in plasma, highlighting an unexpected functional interface between biofilm matrix components and host plasma defense mechanisms.
Authors
- Romy Skusa (ORCID: https://orcid.org/0000-0001-9051-5005)
- Valeria Khaimov (ORCID: https://orcid.org/0000-0001-6686-7676)
- Sonja Oehmcke-Hecht (ORCID: https://orcid.org/0000-0002-3368-6219)
- Katharina Ekat (ORCID: https://orcid.org/0000-0003-2423-201X)
- Marcus Frank
- Holger Rohde
- Christoph Warnke
- Frederike Knipp
- Bernd Kreikemeyer
- Annika Rademacher
- Julia Marcinek
- Selina Tobien
- Lotte Scharnagl
Institutions
- Universität Hamburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Institute for ImplantTechnology and Biomaterials (DE)
- Institute of Medical Microbiology and Hygiene (DE)
- University of Rostock (DE)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-04-14
- DOI
- https://doi.org/10.3389/fcimb.2026.1802218
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00