Efficacy and Safety of Platelet-Rich Plasma in Knee Osteoarthritis: Umbrella Meta-Analysis Based on Clinical Evidence, Methodological Quality and Therapeutic Positioning
: PRP is an effective and safe therapy for knee osteoarthritis, with consistent evidence of superiority over conventional intra-articular treatments. Combined PRP and HA administration suggests superior clinical efficacy compared to monotherapy. Standardization of protocols and appropriate patient selection will be key in future clinical guidelines.
Authors
- Delia Cristóbal Cañadas (ORCID: https://orcid.org/0000-0003-4749-0521)
- Elena María Gázquez-Aguilera
- Bruno José Nievas‐Soriano (ORCID: https://orcid.org/0000-0002-5917-7404)
- David Lozano‐Paniagua (ORCID: https://orcid.org/0000-0002-1046-6483)
- Tesifón Parrón-Carreño (ORCID: https://orcid.org/0000-0003-1951-213X)
- Antonio Fernando Murillo-Cancho (ORCID: https://orcid.org/0000-0002-2436-3856)
- María Ángeles Ventura-García
Institutions
- Complejo Hospitalario Torrecárdenas (ES)
- University of Almería (ES)
Publication Details
- Journal
- Clinics and Practice
- Published
- 2026-04-14
- DOI
- https://doi.org/10.3390/clinpract16040075
- Primary Topic
- Periodontal Regeneration and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00