Targeted Modulation of YAP Signaling: Advancing Small-Molecule Strategies in Oncology and Tissue Regeneration
The Hippo–YAP pathway has emerged as a central regulator of tissue growth and oncogenesis, yet remains resistant to conventional pharmacological targeting. Patent application WO 2026/044133 A1 discloses small-molecule strategies that modulate YAP activity through transcriptional complex disruption and protein stability interference. Robust cellular validation across YAP-dependent cancer models establishes proof of concept for tractable YAP inhibition, with implications spanning oncology and regenerative medicine.
Authors
- Anna C. Renner (ORCID: https://orcid.org/0000-0003-4971-9609)
- Robert B. Kargbo (ORCID: https://orcid.org/0000-0002-5539-6343)
Institutions
- Dakota State University (US)
- North Dakota State University (US)
Publication Details
- Journal
- ACS Medicinal Chemistry Letters
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1021/acsmedchemlett.6c00173
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00