Development and In Vitro Evaluation of Gastroretentive Floating Matrix Tablets of Hydralazine

The purpose of the present study was to develop an optimized gastric floating drug delivery system (GFDDS) containing Hydralazine as a model drug by using various proportions of polymers such as Sodium CMC, Carbopol p934 and HPMC K4M. This was employed to enhance the bioavailability and therapeutic efficacy of the drug. The sustained release formulations of Hydralazine using hydrophobic and hydrophilic polymers were prepared by direct compression method. Optimization of formulation was done by studying effect of drug to polymer ratio on drug release. FT-IR studies indicated absence of any interaction between Hydralazine, polymer (Sodium CMC, Carbopol P 934 and HPMC K4M) and excipients. Nine formulations were prepared and formulation F2 possessed good floating property with total floating time between 8-12 hours. The tablets were also evaluated for its hardness, friability, and in-vitro evaluation test. All parameters complied with IP limits. Results of this study indicated that the combinations of hydrophilic polymers with hydrophobic polymers are suitable to optimize sustained release formulation of Hydralazine. Keywords: Hydralazine, Sodium CMC, Carbopol P934 and HPMC K4M, Floating Tablets