Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury
administration to mice reduced post-MI plasma troponin I and LDH levels, decreased apoptosis, and improved mitochondrial dynamics. Thus, we show that ALY688 enhances EV-mediated cardioprotection through multiple cellular mechanisms including adiponectin delivery, oxidative stress reduction, autophagy restoration, and mitochondrial recovery. These findings provide preclinical evidence supporting the feasibility of evidence for harnessing endogenous repair mechanisms through EVs modulation to mitigate acute cardiovascular injury.
Authors
- Hye Kyoung Sung
- Augusto Zani (ORCID: https://orcid.org/0000-0003-2283-9846)
- Eddie Tam (ORCID: https://orcid.org/0009-0002-8480-7145)
- Erin E. Mulvihill (ORCID: https://orcid.org/0000-0002-3981-0241)
- Yubin Lei (ORCID: https://orcid.org/0000-0002-4468-8076)
- Fengxia Xiao (ORCID: https://orcid.org/0000-0002-4070-2432)
- Nadya M. Morrow
- Gary Sweeney (ORCID: https://orcid.org/0000-0002-1946-1347)
- Wing Yan Chung
- Jialing Tang
- Serena M. Pulente
- Ilka Lorenzen‐Schmidt
- Dylan Burger
- Khang Nguyen
Institutions
- University of Ottawa (CA)
- York University (CA)
- Ottawa Hospital (CA)
- Hospital for Sick Children (CA)
Publication Details
- Journal
- Advanced Healthcare Materials
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1002/adhm.202505837
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canadian Institutes of Health Research