Structural basis of transcription-coupled RNA damage by incorporation of oxidized ribonucleotides
-conformation to form a Watson-Crick pair with a dC template. Collectively, our work demonstrates that nucleotide-pool oxidation can directly affect Pol II fidelity control steps and elongation dynamics and induce RNA damage in a transcription-coupled manner.
Authors
- Peini Hou (ORCID: https://orcid.org/0000-0002-5214-8029)
- C K Lee
- Juntaek Oh (ORCID: https://orcid.org/0000-0002-7625-2779)
- Dong Wang (ORCID: https://orcid.org/0000-0002-2829-1546)
- Jenny Chong
Institutions
- Kyung Hee University (KR)
- University of Montana (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1073/pnas.2602266123
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation of Korea
- National Institute of General Medical Sciences