Functional and Expression Studies of iPSC-Derived Cardiomyocytes Carrying a Novel HCM-Associated MYPN Genetic Variant
plays a dual role in hypertrophic cardiomyopathy pathogenesis, disrupting not only sarcomeric and cytoskeletal organization but also the regulation of the muscle gene program.
Authors
- D.A. Kudlay
- Suren M. Zakian (ORCID: https://orcid.org/0000-0003-2448-6511)
- Maxim Ri (ORCID: https://orcid.org/0000-0003-2403-884X)
- Anastasia K. Zaytseva (ORCID: https://orcid.org/0000-0001-7729-0219)
- Yuri V. Vyatkin (ORCID: https://orcid.org/0000-0002-9056-8796)
- Anna Zlotina (ORCID: https://orcid.org/0000-0002-2029-1197)
- S. I. Tarnovskaya (ORCID: https://orcid.org/0000-0002-6777-0785)
- Dmitriy N. Shtokalo
- Ekaterina Nikitina
- M Yu Sorokina
- Ekaterina S. Klimenko
- Anna A. Kostareva
- Elena V. Dementyeva
Institutions
- Real Academia Española (ES)
- Institute of Evolutionary Physiology and Biochemistry (RU)
- Sechenov University (RU)
- Lomonosov Moscow State University (RU)
- Karolinska Institutet (SE)
- Federal Almazov North-West Medical Research Centre (RU)
- Institute of Chemical Biology and Fundamental Medicine (RU)
- Institute of Immunology and Physiology (RU)
- Institute of Cytology and Genetics (RU)
- Siberian Branch of the Russian Academy of Sciences (RU)
- Cellular Research (United States) (US)
- Institut de Biologie Moléculaire et Cellulaire (FR)
- Novelis (Canada) (CA)
Publication Details
- Journal
- Genes
- Published
- 2026-04-14
- DOI
- https://doi.org/10.3390/genes17040456
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Siberian Branch, Russian Academy of Sciences
- Russian Science Foundation