TOLLIP and MUC5B single nucleotide polymorphisms among interstitial lung disease patients from Western India

Background: among patients with interstitial lung disease (ILD) and its subtypes. Additionally, it investigated the relationship between these genetic variants and inflammatory biomarkers, as well as the patterns of linkage disequilibrium (LD) in patients with ILD from Western India. Methods: , and IL-6) were measured using a multiplex bead-based immunoassay. LD was assessed using Haploview software. Results: rs35705950 G/G homozygous genotypes in patients with ILD. Furthermore, LD analysis revealed no significant haplotype blocks in this population. Conclusion: genotypes in Indian patients with ILD, highlighting genotype-driven variation in IFN-γ and distinct allele-frequency patterns compared to Western cohorts. This study also indicated that one-third of the Indian patients with ILD, higher than the 6-7% from currently available Asian data, had genotypes that may benefit from NAC therapy.