Synthesis of 4-Hydroxyphenylamino-Naphthoquinones as Paracetamol-Inspired Analogs: Chemical, In Silico, and Phenotypic Pharmacological Evaluation
: Overall, these findings indicated that the 4-hydroxyphenylamino-naphthoquinone scaffold emerges as a promising non-opioid platform for peripheral inflammatory pain, supporting further investigation of its pharmacological and mechanistic properties.
Authors
- Jaime A. Valderrama
- Cinthya Enríquez (ORCID: https://orcid.org/0000-0002-9839-7389)
- Julio Benites (ORCID: https://orcid.org/0000-0002-8562-0078)
- Iván M. Quispe-Díaz (ORCID: https://orcid.org/0000-0001-8515-0654)
- Elena Mantilla‐Rodríguez (ORCID: https://orcid.org/0000-0002-9925-0581)
- Daniel Asunción‐Alvarez (ORCID: https://orcid.org/0000-0001-7498-2121)
- Wilfredo O. Gutiérrez-Alvarado (ORCID: https://orcid.org/0000-0002-1240-7612)
- Sussan Lopez-Mercado
- Roberto O. Ybañez-Julca
- Ricardo Pino-Rios
- Oswaldo Rebaza-Rioja
Institutions
- Universidad Andrés Bello (CL)
- Universidad Nacional de la Amazonía Peruana (PE)
- National University of Trujillo (PE)
- Arturo Prat University (CL)
Publication Details
- Journal
- Pharmaceutics
- Published
- 2026-04-14
- DOI
- https://doi.org/10.3390/pharmaceutics18040482
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad Nacional de Trujillo
- Universidad Arturo Prat
- Agencia Nacional de Investigación y Desarrollo