High glucose impairs cognitive function through Creb3 O-GlcNAcylation and increased lactate production
in Creb3 with a short peptide alleviated these effects. This study elucidates a mechanistic link between high glucose-induced Creb3 O-GlcNAcylation and Ldha-mediated lactate production, offering a potential therapeutic strategy for managing diabetes-related cognitive dysfunction.
Authors
- Liuyu Kuang
- Qiongsui Zhong
- Yuanmei Zhong
- Ya Hui
- Jingxi Xu
- Yuqi Hao
- Jingxue Cao
- Xiaoyun Zeng
- Biwen Mo
- Y Gao
- Rongrong Nie
- Xing Yang
- Tianpeng Zheng (ORCID: https://orcid.org/0000-0001-6068-4780)
Institutions
- Guilin Medical University (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Science Signaling
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1126/scisignal.adx4313
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China