Associations of Depressive Symptom Severity with High-Sensitivity C-Reactive Protein Among U.S. Adults: NHANES 2015–2018
Higher depressive symptom severity was associated with higher hs-CRP and a higher prevalence of low-grade systemic inflammation in U.S. adults, with the clearest elevations observed among those with moderately severe symptoms. For the pre-specified moderate-symptom contrast, point estimates were modest and sensitive to handling of high hs-CRP values and adiposity-related adjustment.
Authors
- Omar Rozo-Pérez
- Valmore Bermúdez (ORCID: https://orcid.org/0000-0003-1880-8887)
- Diego Rivera-Porras (ORCID: https://orcid.org/0000-0003-2169-3208)
- Daniel Cepeda-Pineda (ORCID: https://orcid.org/0009-0006-8677-2731)
- Astrid Rozo-Sánchez
- Sandra-Milena Carrillo-Sierra
Institutions
- Universidad de La Sabana (CO)
- University of the Coast (CO)
- Universidad Simón Bolívar (CO)
- University of Pamplona (CO)
Publication Details
- Journal
- Journal of Clinical Medicine
- Published
- 2026-04-14
- DOI
- https://doi.org/10.3390/jcm15082975
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00