UPLC-Q-TOF/MS-Based Metabolomics and 16S rRNA Profiling Reveal that Corosolic Acid Ameliorates High-Fat Diet-Induced MASLD by Modulating the Gut-Liver Axis to Inhibit the cGAS-STING Pathway
). Mechanistically, HAD-Car alleviated MASLD by inhibiting the cGAS-STING pathway. Collectively, CA exerts anti-MASLD effects via regulating gut microbiota and metabolites, offering new insights into MASLD treatment.
Authors
- Wei Jia (ORCID: https://orcid.org/0000-0002-3739-8994)
- Zihao Chen (ORCID: https://orcid.org/0000-0002-9349-0349)
- Yanlong Chen (ORCID: https://orcid.org/0000-0003-1798-5398)
- Qiongfeng Liao
- Zhiyong Xie (ORCID: https://orcid.org/0000-0002-2147-6660)
- Jingheng Chen
- Jingtao Yu
- Xingyuan Zhang
- Kaiwei Cai
- Pei Li
- Aihua Huang
- Song Deng
Institutions
- Guangzhou University of Chinese Medicine (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Yueqing People's Hospital (CN)
Publication Details
- Journal
- Journal of Agricultural and Food Chemistry
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1021/acs.jafc.5c13513
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangzhou Municipal Science and Technology Project
- Basic and Applied Basic Research Foundation of Guangdong Province