Crosstalk between autophagy-dependent ferroptosis and PANoptosis in myocardial and cerebral ischemia-reperfusion injury: mechanisms and therapeutic implications
interactions and clinical translational potential of these mechanisms remain to be further validated. We propose that future therapeutic strategies may shift from targeting individual pathways to intervening at critical crosstalk nodes, offering a new direction for developing more effective protective strategies against IRI in the heart, brain, and beyond.
Authors
- Yin Fu
- Qiang Fu
- Zhe Zhang
- Yuntian Xie
- Aidi Li
- Taoran Mo
- Bojia Li
- Xue Fang
- Yidi Ma
Institutions
- Heilongjiang University of Chinese Medicine (CN)
- First Affiliated Hospital of Heilongjiang University of Chinese Medicine (CN)
- Heilongjiang University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-04-14
- DOI
- https://doi.org/10.3389/fphar.2026.1744884
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Heilongjiang Province
- Science and Technology Department, Heilongjiang Province