Asparagus racemosus Root Extract (SheVari4®) Alleviates Menopausal Symptoms in Pre-, Peri-, and Post-menopausal Healthy Women

root extract (SheVari4®) in improving menopausal symptoms across somatic, psychological, and urogenital domains. A total of 60 healthy (pre-, peri-, and post-menopausal) women aged 40-55 years were recruited and randomized into two groups to receive daily doses of either 100 mg of placebo or SheVari4® via double-blinded administration. Menopausal symptoms were assessed at baseline (pre-treatment), and at four and eight weeks (post-treatment), using the Menopause Rating Scale (MRS). Results Confirming successful randomization, both groups reported similar baseline MRS scores (~15 on a 44-point scale). However, post-treatment, the SheVari4® group demonstrated a significant reduction in menopausal symptom severity at week 4 (43% decrease) and at week 8 (71% decrease, linear mixed model (LMM) analysis, p < 0.001). Additionally, several parameters across MRS subscales showed significant improvement with SheVari4®, including hot flash occurrence and sleep quality (both >90% improved at week 8). Adverse events were mild, transient, and comparable between groups, with gastrointestinal discomfort being the most common. Conclusion These findings suggest that SheVari4® may represent a promising botanical alternative for women seeking non-HRT approaches to manage menopausal symptoms.