Chemoenzymatic Triazolopyridine Synthesis Enabled by Cryptic Diazo Formation by Vanadium-Dependent Haloperoxidases
generation of 2-pyridyl ketone hydrazones followed by VHPO-catalyzed oxidative cyclization to give [1,2,3]triazolo[1,5a]pyridines in high yield and chemoselectivity.
Authors
- Manik Sharma (ORCID: https://orcid.org/0000-0003-1951-4274)
- Kyle F. Biegasiewicz (ORCID: https://orcid.org/0000-0003-1905-1919)
Institutions
- Emory University (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1021/acs.orglett.6c00937
- Primary Topic
- Vanadium and Halogenation Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Emory University
- National Institute of General Medical Sciences