Andrographolide Suppresses Influenza A Virus-Induced Pyroptosis via PI3K/AKT-Mediated Caspase-3/GSDME Inactivation
: These findings reveal a novel host-directed mechanism by which andrographolide alleviates IAV-induced immunopathology by activating the PI3K/AKT pathway, thereby suppressing caspase-3/GSDME-dependent pyroptosis. Thus, this axis represents a promising target for controlling excessive inflammation in severe influenza.
Authors
- Zhenqiao Wei
- Xiaochang Zhang
- Yuke Cui (ORCID: https://orcid.org/0000-0003-0150-3438)
- Changdong Zhou
- Liang Guo (ORCID: https://orcid.org/0000-0002-8748-5770)
- Yaling Xing
- Shengqi Wang
- Yuanyuan Jiao
- Jingqi Shi
- Qingyu Li
- Chenhui Wang (ORCID: https://orcid.org/0000-0002-7527-4028)
- Qi He
- Wen Yang
- Zhen Sun
Institutions
- Xinxiang University (CN)
- State Key Laboratory of Kidney Diseases
Publication Details
- Journal
- Biomedicines
- Published
- 2026-04-13
- DOI
- https://doi.org/10.3390/biomedicines14040887
- Primary Topic
- Andrographolide Research and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China