Novel Combination of <scp>UVA</scp> ‐1 Phototherapy With Topical Tofacitinib for Treating Eosinophilic Fasciitis With Morphea: Case Report

Eosinophilic fasciitis (EF) and morphea are rare sclerosing connective tissue disorders, and there remains debate about whether these entities are pathologically distinct or related. This case report describes the successful treatment of an adolescent patient who developed progressive morphea plaques while being treated with systemic corticosteroids, intravenous immunoglobulin, and methotrexate for EF. A novel combination of topical tofacitinib, a Janus kinase (JAK) inhibitor, and UVA-1 phototherapy induced clinical remission and was well tolerated, warranting further investigation into such combination therapy.

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Publication Details

Journal
Pediatric Dermatology
Published
2026-04-13
DOI
https://doi.org/10.1111/pde.70220
Primary Topic
Eosinophilic Disorders and Syndromes
Type
article
Field-Weighted Citation Impact
0.00
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article

Novel Combination of UVA ‐1 Phototherapy With Topical Tofacitinib for Treating Eosinophilic Fasciitis With Morphea: Case Report

Frankie O. G. Fraulin, Michele Ramien, Nadia Luca, Ye‐Jean Park et al.
Pediatric Dermatology
Eosinophilic Disorders and Syndromes
article

Novel Combination of UVA ‐1 Phototherapy With Topical Tofacitinib for Treating Eosinophilic Fasciitis With Morphea: Case Report

Frankie O. G. Fraulin, Michele Ramien, Nadia Luca, Ye‐Jean Park, Daphne Cheung, Marie‐Anne Bründler
article en

Abstract

Eosinophilic fasciitis (EF) and morphea are rare sclerosing connective tissue disorders, and there remains debate about whether these entities are pathologically distinct or related. This case report describes the successful treatment of an adolescent patient who developed progressive morphea plaques while being treated with systemic corticosteroids, intravenous immunoglobulin, and methotrexate for EF. A novel combination of topical tofacitinib, a Janus kinase (JAK) inhibitor, and UVA-1 phototherapy induced clinical remission and was well tolerated, warranting further investigation into such combination therapy.

Pediatric Dermatology
University of Toronto (CA), Alberta Children's Hospital (CA)
Good health and well-being
Openalex Percentile: Top 25%
Eosinophilic Disorders and Syndromes
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