Diversity-Oriented Synthesis of CF <sub>3</sub> -Functionalized Polycyclic Spiroisoxazolones via Organobase-Promoted Vinylogous Michael Addition Cascade Reactions
-tethered enediones. Additionally, the asymmetric variant of the spiro-fused isoxazolone scaffolds was also achieved using a bifunctional squaramide catalyst. Control experiments confirmed the reversibility and stability of the hemiketal and ketal groups in spiroisoxazolones. Gram-scale synthesis and derivatization further demonstrated the synthetic utility.
Authors
- Yadav Kacharu Nagare (ORCID: https://orcid.org/0000-0002-2752-7457)
- Chengcai Liu
- Chia-Yen Chang
- Ganesh Shantaram Khomane (ORCID: https://orcid.org/0009-0005-0790-1148)
- Tzu-Chun Yen
- Wei-Chi Wu
Institutions
- National Taiwan Normal University (TW)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1021/acs.joc.6c00026
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science and Technology Council