Investigation of iterative deconvolution in 177Lu-SPECT imaging for lesion dosimetry

AIM/INTRODUCTION: Lu-SPECT based tumor dosimetry. MATERIALS/METHODS: Lu]Lu-PSMA-I&T (y = 10) treatment, in order to evaluate its impact on AD estimates. Lesion AD from the original reconstruction (OR) and OR + LRD were estimated using MIM SurePlan™ MRT. The AD from OR, OR + LRD, and OR + RC (phantom-based recovery correction based on volume) were compared. RESULTS: Lu]Lu-PSMA-I&T: y = 56). For OR + LRD and OR + RC an average increase of 22 ± 12% and 57 ± 36% of tumor AD was found. CONCLUSION: Lu-SPECT based dosimetry. Further studies are necessary to investigate the effect of different PVC methods, such as LRD or phantom-based correction factors, on overall uncertainty of lesion ADs.

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Publication Details

Journal
EJNMMI Physics
Published
2026-04-13
DOI
https://doi.org/10.1186/s40658-026-00865-5
Primary Topic
Radiopharmaceutical Chemistry and Applications
Type
article
Field-Weighted Citation Impact
0.00

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article

Investigation of iterative deconvolution in 177Lu-SPECT imaging for lesion dosimetry

Zachary Ells, A Harbach, Maximilian Scheifele, Grigory Liubchenko et al.
EJNMMI Physics
Radiopharmaceutical Chemistry and Applications
article

Investigation of iterative deconvolution in 177Lu-SPECT imaging for lesion dosimetry

Zachary Ells, A Harbach, Maximilian Scheifele, Grigory Liubchenko, Gabriel T. Sheikh, Mikhail Rumiantcev, Sibylle Ziegler, Astrid Delker, Mathias J. Zacherl, Sandra Resch, Sophie C. Siegmund, G Böning, L Unterrainer, Matthias Brendel, Rudolf A. Werner, Angelica Noto
article en

Abstract

AIM/INTRODUCTION: Lu-SPECT based tumor dosimetry. MATERIALS/METHODS: Lu]Lu-PSMA-I&T (y = 10) treatment, in order to evaluate its impact on AD estimates. Lesion AD from the original reconstruction (OR) and OR + LRD were estimated using MIM SurePlan™ MRT. The AD from OR, OR + LRD, and OR + RC (phantom-based recovery correction based on volume) were compared. RESULTS: Lu]Lu-PSMA-I&T: y = 56). For OR + LRD and OR + RC an average increase of 22 ± 12% and 57 ± 36% of tumor AD was found. CONCLUSION: Lu-SPECT based dosimetry. Further studies are necessary to investigate the effect of different PVC methods, such as LRD or phantom-based correction factors, on overall uncertainty of lesion ADs.

EJNMMI PhysicsVol. 13(1)
Johns Hopkins University (US), German Cancer Research Center (DE), Heidelberg University (DE), Johns Hopkins Medicine (US), German Center for Neurodegenerative Diseases (DE), LMU Klinikum (DE), Medizinische Hochschule Hannover (DE), Bavarian Broadcasting (DE), Munich Cluster for Systems Neurology (DE), Molecular Theranostics (United States) (US), Deutsches Konsortium für Translationale Krebsforschung (DE), Ludwig-Maximilians-Universität München (DE)
Deutsche Forschungsgemeinschaft
Openalex Percentile: Top 21%
Radiopharmaceutical Chemistry and Applications
DOIOpen Access PDFOpenAlex
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