Spatial Detection of Microsphere Polystyrene Plastics and Molecular Remodeling within a Full‐Body Mouse with MALDI Trapped Ion Mobility Mass Spectrometry Imaging
)) reflect disrupted sphingolipid and ether-linked lipid species metabolism and altered lipid transport. Together, these findings reveal dynamic, tissue-specific lipid responses to PS exposure. This study shows that MALDI TIMS MSI provides high-resolution, label-free mapping of PS and its metabolic footprint and can be extended to other low-abundance synthetic compounds.
Authors
- Ming-Fo Hsu (ORCID: https://orcid.org/0000-0001-8504-8297)
- Elizabeth K. Neumann (ORCID: https://orcid.org/0000-0002-6078-3321)
- Fawaz G. Haj (ORCID: https://orcid.org/0000-0001-9641-7836)
- Amy Parkhurst
- Karina A. Vargas
- Christopher Hou
Institutions
- Western Human Nutrition Research Center (US)
- University of California, Davis (US)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1002/anie.6528604
- Primary Topic
- Mass Spectrometry Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- University of California, Davis