Inactivation of a purine biosynthesis repressor promotes ribosome synthesis to overcome antibiotic stress
single-nucleotide polymorphisms across multiple species have been associated with antibiotic resistance, no study has directly linked these sequence polymorphisms to their regulatory function. Our results highlight the critical role of ribosome abundance and nucleotide metabolism in shaping antibiotic efficacy.
Authors
- Yongjun Tan (ORCID: https://orcid.org/0009-0006-2361-1498)
- D Zhang
- Jue D. Wang (ORCID: https://orcid.org/0000-0003-1503-170X)
- Mee‐Ngan F. Yap (ORCID: https://orcid.org/0000-0003-4213-4050)
- Alexandre Le Scornet
Institutions
- University of Wisconsin–Madison (US)
- UCLouvain Saint-Louis Brussels (BE)
- Saint Louis University (US)
Publication Details
- Journal
- mBio
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1128/mbio.00118-26
- Primary Topic
- RNA and protein synthesis mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Northwestern University
- Saint Louis University
- National Institutes of Health