In silico exploration of electric field distribution in tDCS: integrating white matter anisotropy and subject-specific structural connectivity

< 0.05) correlation between EF focality and the strength of connectivity between cortical areas below P2 and P1 electrodes. Significance-These findings highlight the importance of including white matter anisotropy into tDCS simulation to prevent distortions in EF distribution and suggest the need to integrate structural connectivity information into the definition of subject-specific dose in tDCS protocols.