Responsible cell type in murine PAF-induced systemic anaphylaxis
Platelet-activating factor (PAF) is a key mediator of systemic anaphylaxis. The principal target cell type of PAF in systemic anaphylaxis remains unclear. Endothelial cell-specific PAFR-deficient mice were protected from mortality in PAF-induced systemic anaphylaxis. Endothelial PAFR is suggested to be the principal target mediating PAF-driven mortality in systemic anaphylaxis.
Authors
- Hideo Shindou (ORCID: https://orcid.org/0000-0002-3443-913X)
- Keisuke Yanagida
- Takao Shimizu
- Tomoyuki Suzuki
Institutions
- National Center for Global Health and Medicine (JP)
Publication Details
- Journal
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1016/j.bbalip.2026.159744
- Primary Topic
- Food Allergy and Anaphylaxis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Takeda Science Foundation
- National Center for Global Health and Medicine