SCD1 licenses STING signaling through fatty acid desaturation–mediated membrane remodeling
-deficient models. Our findings establish SCD1-mediated lipid desaturation as a fundamental regulator of STING-driven immunity, highlighting its therapeutic potential for disorders of aberrant STING activation.
Authors
- Chengjiang Gao (ORCID: https://orcid.org/0000-0002-9365-4497)
- Mutian Jia (ORCID: https://orcid.org/0000-0002-2652-3411)
- Yu Fu (ORCID: https://orcid.org/0000-0002-2413-3858)
- Hui Song (ORCID: https://orcid.org/0000-0003-2203-8440)
- Danhui Qin
- Ying Qin (ORCID: https://orcid.org/0000-0001-6359-0886)
- Haojia Jiang
- Xintong Meng (ORCID: https://orcid.org/0009-0008-9479-3617)
- Chunyuan Zhao
Institutions
- Shandong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Ministry of Education (BD)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1073/pnas.2528843123
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China