Detection rate of [99mTc]Tc-PSMA SPECT/CT in prostate cancer: a systematic review and a meta-analysis

Background/objective: Tc]Tc-PSMA SPECT/CT in PCa patients. Methods: Tc]Tc-PSMA SPECT/CT in patients affected by PCa. Results: Tc]Tc-PSMA SPECT/CT in the staging field was 79.7% (95% CI 70.2-89.3%); in restaging biochemical recurrence was 75.4% (95% CI 67.7-83%). A significant statistical heterogeneity was reported in both analyses. PSA value at the time of SPECT/CT was frequently associated with the DR. Conclusions: Tc]Tc-PSMA SPECT/CT is a good diagnostic tool for prostate cancer, both at staging and biochemical recurrence. It may be useful as an alternative in resource-constrained environments or remote locations where PET/CT technology is not readily accessible.