Confrontations between <i>Aspergillus nidulans</i> and microbial biocontrol agents cause differential regulation of secondary metabolism and synthesis of chemicals toxic to human kidney and colon cells
confronting various microorganisms, including microbial biological control agents. Strong modulations of transcript abundances of genes belonging to secondary metabolism gene clusters correlated with the formation of a vast array of novel secondary metabolites. Compounds formed in some confrontations were toxic to human cells, questioning the consumer safety of applying microbial biological control agents.
Authors
- Lena Hartmann
- H. B. Deising (ORCID: https://orcid.org/0000-0001-5789-4269)
- Robert C. Rennert (ORCID: https://orcid.org/0000-0003-3665-6696)
- Henriette Uthe (ORCID: https://orcid.org/0000-0002-2523-196X)
- Yvonne Poeschl (ORCID: https://orcid.org/0000-0002-6727-6891)
- Bennet Rohan Fernando Devasahayam (ORCID: https://orcid.org/0000-0002-8066-0425)
Institutions
- Luther University (KR)
- German Centre for Integrative Biodiversity Research (DE)
- Leibniz Institute of Plant Biochemistry (DE)
- Martin Luther University Halle-Wittenberg (DE)
Publication Details
- Journal
- Applied and Environmental Microbiology
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1128/aem.02180-25
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00