A NIR‐Gated Nanogenerator Enables Low‐Dose Nitric Oxide‐Potentiated Phototherapy
). This synergistic ROS/RNS surge targets mitochondria, inducing membrane depolarization and rapid ATP depletion to trigger apoptosis. Guided by NIR-II fluorescence imaging, this multi-modal therapy achieves efficient tumor ablation in vivo, validating a potent low-dose strategy for integrating controlled gas release with phototherapy.
Authors
- Yanxin Wu
- Chendong Ji (ORCID: https://orcid.org/0000-0003-4913-1645)
- Pengyu Li (ORCID: https://orcid.org/0000-0002-3193-2957)
- Li Ouyang
- Meizhen Yin
- Jin Zhang
Institutions
- Beijing University of Chemical Technology (CN)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1002/anie.7993582
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities