Candexch algorithm-enhanced chemometric determination of a novel anti-COVID-19 therapeutics in plasma and paxlovid formulation using advanced multivariate modeling: a sustainability-centered bioanalytical approach

dosage matrices. Multidimensional sustainability appraisal revealed favorable environmental and operational attributes. The method satisfied all National Environmental Methods Index criteria, achieved a Greenness Evaluation Metric for Analytical Methods score of 7.502, and displayed a calculated carbon footprint of 0.021 kg CO₂/sample. Complementary operational and innovation assessments yielded Blue Applicability Grade Index and Violet Innovation Grade Index scores of 90.00 and 80.00, respectively, while the integrated Normalized Quality Score reached 83%. Collectively, the developed platform provides a cost-efficient and environmentally considerate analytical approach suitable for pharmaceutical quality control and preliminary bioanalytical screening in fortified plasma matrices, particularly in laboratories lacking access to advanced chromatographic instrumentation.