Unveiling the Role of Irisin as a Biomarker in Adolescent and Young Adult <scp>PCOS</scp> : A Metabolic and Hormonal Comparison of Hyperandrogenic and Normoandrogenic Phenotypes

AIM: Polycystic ovary syndrome (PCOS) in adolescents and young adults is difficult to diagnose due to overlap with normal puberty. This study assessed irisin as a biomarker, comparing metabolic and hormonal profiles of hyperandrogenic (HA) and normoandrogenic (NA) phenotypes, determining an optimal cut-off, examining correlations with clinical markers, and identifying predictors of irisin levels. METHODS: A cross-sectional study was conducted involving 120 females aged 13-21 years, comprising 60 PCOS patients (38 HA-PCOS, 22 NA-PCOS) and 60 healthy controls. Metabolic and hormonal profiles, including serum irisin, insulin resistance indices, lipid profile, and reproductive hormones were assessed. Data were analyzed using SPSS version 22. RESULTS: = 0.908). CONCLUSION: HA-PCOS is marked by more severe metabolic disruption. Irisin may serve as a promising early biomarker for this phenotype and help predict long-term complications linked to metabolic disruption in PCOS.