Discovery of p-Coumaric Acid as a Candidate Cholesterol-Lowering Factor in Germinated Brown Rice via Untargeted Metabolomics Combined with a Cholesterol-Induced HepG2 Cell Model
< 0.05). Untargeted metabolomics and subsequent validation suggested that p-coumaric acid is a candidate bioactive compound contributing to the cholesterol-lowering effect of GBR. Further analysis indicated that this effect may be associated with modulation of the mRNA expression levels of SREBP2, HMGCR, and LDLR. These findings indicate that germination enhances the bioactivity of brown rice in a cultivar-dependent manner and provides supporting evidence for the potential application of GBR as a functional food ingredient for lipid management.
Authors
- Yan Li (ORCID: https://orcid.org/0000-0002-9402-1093)
- Mingcong Fan (ORCID: https://orcid.org/0000-0002-6730-5576)
- Linlin Wang (ORCID: https://orcid.org/0000-0002-7014-2149)
- Yixuan Yan
- Xiangyu Pang
- Haifeng Qian
- Ningxin Ding
Institutions
- State Key Laboratory of Food Science and Technology (CN)
Publication Details
- Journal
- Foods
- Published
- 2026-04-13
- DOI
- https://doi.org/10.3390/foods15081344
- Primary Topic
- GABA and Rice Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Jiangnan University
- State Key Laboratory of Food Science and Technology
- Qinglan Project of Jiangsu Province of China
- Earmarked Fund for China Agriculture Research System
- Collaborative Innovationcenter of Food Safety and Quality Control in Jiangsu Province