Metformin exacerbates diabetic amyotrophy via oxidative stress and gut microbiota alterations
Illustration depicts a mechanistic pathway where metformin affects Desulfovibrio bacteria, leading to increased hydrogen sulfide production. This crosses the intestinal barrier, activates NOS1, induces 3-NT formation, and increases oxidative stress in the gastrocnemius muscle.
Authors
- Abdul Haseeb (ORCID: https://orcid.org/0000-0001-9658-3690)
- Jiangang Zheng
- Wafa Yousaf
- Ziyang Wang (ORCID: https://orcid.org/0000-0003-4679-3125)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Zhigang Cao
Institutions
- Shanxi Agricultural University (CN)
- Xinjiang Medical University (CN)
- Changzhi Medical College (CN)
- Shanxi Science and Technology Department (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-04-13
- DOI
- https://doi.org/10.3389/fmicb.2026.1778515
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00