Peptidomimetic Long-Acting Growth Hormone-Releasing Hormone Agonists Promote Tissue Perfusion in Hindlimb Ischemia
> 24 h). Subcutaneous administration of selected peptides in mice with ischemic hindlimb enhanced blood perfusion and preservation of limb function. They also promoted endothelial regeneration and collateral vessel formation, enhancing vascular remodeling and tissue repair. In vitro, the peptides enhanced the angiogenic potential of endothelial cells, primarily through activation of the ERK signaling pathway. Our findings lay a strong foundation for the development of long-acting GHRH-R agonists with promising therapeutic potential for the treatment of vascular and regenerative disease.
Authors
- Xiaoke Niu (ORCID: https://orcid.org/0000-0002-1249-4728)
- Peng Teng (ORCID: https://orcid.org/0000-0002-7412-9646)
- Haodong Shao
- Bo Wang (ORCID: https://orcid.org/0000-0001-8013-1403)
- Jianhua Zhang (ORCID: https://orcid.org/0000-0001-7844-6035)
- Xing Su (ORCID: https://orcid.org/0009-0005-9973-9538)
- H-T Yu
- Yinyin Wu (ORCID: https://orcid.org/0009-0000-7107-4830)
- Zhitao Guo
- Meng Chen
- Mengyu Mao
- Jiayan Luo
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Jinhua Academy of Agricultural Sciences (CN)
- Zhejiang Lab (CN)
- Drug Discovery Laboratory (Norway) (NO)
- Kindeva Drug Delivery (United States) (US)
- Zhejiang University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1021/acs.jmedchem.5c03408
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Zhejiang University
- Natural Science Foundation of Zhejiang Province