Light-Mediated In Situ Synchronous Capture of Antigens and Nucleic Acids as Nanovaccines to Boost Tumor Radioimmunotherapy

generated from Ce6 upon a 660 nm laser irradiation, fAuNPs-Ce6 nanoparticles can capture the tumor-derived protein antigens and nucleic acid fragments simultaneously through the furan-mediated covalent reactions with amino group or nucleobase, which significantly prolongs the retention time of antigens and adjuvants in the tumor microenvironment, promoting robust DC maturation without exogenous adjuvants and eliciting potent systemic antitumor immunity. More notably, these nanovaccines in combination with PD-L1 blockade can remarkably enhance the radiotherapeutic efficacy, achieving significant suppression of both primary and distant tumor growth. Therefore, this light-mediated in situ vaccination may offer a promising strategy for the precise treatment of malignant tumors.

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Publication Details

Journal
Journal of the American Chemical Society
Published
2026-04-13
DOI
https://doi.org/10.1021/jacs.5c21345
Primary Topic
Nanoplatforms for cancer theranostics
Type
article
Field-Weighted Citation Impact
0.00

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article

Light-Mediated In Situ Synchronous Capture of Antigens and Nucleic Acids as Nanovaccines to Boost Tumor Radioimmunotherapy

Xingxiang Ren, Jinfeng Zhu, Xiaju Cheng, Danyang Ji et al.
Journal of the American Chemical Society
Nanoplatforms for cancer theranostics
article

Light-Mediated In Situ Synchronous Capture of Antigens and Nucleic Acids as Nanovaccines to Boost Tumor Radioimmunotherapy

Xingxiang Ren, Jinfeng Zhu, Xiaju Cheng, Danyang Ji, Zhengzhong Lv, Yongxiang Bai, Yiming Feng, Miao Li, Haibin Shi, Zhixin Han, Yuqi Zhang, Yan Chen, Yurong Fan, Hongyuan Wen
article en

Abstract

generated from Ce6 upon a 660 nm laser irradiation, fAuNPs-Ce6 nanoparticles can capture the tumor-derived protein antigens and nucleic acid fragments simultaneously through the furan-mediated covalent reactions with amino group or nucleobase, which significantly prolongs the retention time of antigens and adjuvants in the tumor microenvironment, promoting robust DC maturation without exogenous adjuvants and eliciting potent systemic antitumor immunity. More notably, these nanovaccines in combination with PD-L1 blockade can remarkably enhance the radiotherapeutic efficacy, achieving significant suppression of both primary and distant tumor growth. Therefore, this light-mediated in situ vaccination may offer a promising strategy for the precise treatment of malignant tumors.

Journal of the American Chemical SocietyVol. 148(15)
Soochow University (CN), Environmental Protection Engineering (Greece) (GR), Second Affiliated Hospital of Soochow University (CN)
National Natural Science Foundation of China, Natural Science Foundation of Jiangsu Province, Soochow University, Priority Academic Program Development of Jiangsu Higher Education Institutions, Science and Technology Support Program of Jiangsu Province, Basic Research Program of Jiangsu Province, Natural Science Research of Jiangsu Higher Education Institutions of China, Science and Technology Program of Suzhou
Good health and well-being
Openalex Percentile: Top 27%
Nanoplatforms for cancer theranostics
DOISourceOpenAlex
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