EXOC5/SEC10 attenuates antiviral IFN-I signaling by targeting STING1 for autophagic degradation
BafA1: bafilomycin A1; BMDMs: bone marrow-derived macrophages; cGAMP: cyclic GMP-AMP; CGAS: cyclic GMP-AMP synthase; EXOC5/SEC10: exocyst complex component 5; HAdV-4: human adenovirus type 4; HSV-1: herpes simplex virus type 1; HT-DNA: herring testis deoxyribonucleic acid; IFN: interferon; IRF3: interferon regulatory factor 3; ISD: interferon stimulatory DNA; PMs: peritoneal macrophages; siRNA: small interfering RNA; SQSTM1/p62: sequestosome 1; TBK1: TANK binding kinase 1; VACV70: 70-mers of dsDNA representing the genome of vaccinia virus.
Authors
- Daniel Chang He
- Yuchen Li (ORCID: https://orcid.org/0000-0002-1594-2717)
- Xiao Ying Yu
- Luteng He
- Yanan Xu
- Fachao Sun
- Jie Yu
- Wenqing Ma
- Hongbin He (ORCID: https://orcid.org/0000-0002-7438-0638)
Institutions
- University of North Carolina at Chapel Hill (US)
- Shandong Normal University (CN)
- Shandong Agricultural University (CN)
Publication Details
- Journal
- Autophagy
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1080/15548627.2026.2659292
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province