Wheat Peptides Promote Recovery of the Enteric Nervous System via mAChR Activation to Relieve Constipation in Mice
). Three-dimensional imaging substantiated WP-induced augmentation of enteric neurons in constipated colons. Collectively, these results indicate that WP alleviates constipation through a multitarget mechanism involving muscarinic receptor activation, potentiation of calcium-dependent signaling, and promotion of enteric nervous system recovery, which collectively restore normal intestinal motility. WP thus emerges as a promising therapeutic candidate for constipation management.
Authors
- Qianqian Wang (ORCID: https://orcid.org/0000-0001-6283-2257)
- Guanghua He (ORCID: https://orcid.org/0000-0002-2650-3007)
- M. J. Zhao
- Haiying Cai
- Haobin Zhao
- Lida Wang
- Jing Wang
- Fei Shen
- Juan Du
- Fengqin Feng (ORCID: https://orcid.org/0000-0002-9770-1721)
Institutions
- Zhejiang A & F University (CN)
- Zhejiang University of Science and Technology (CN)
- Food Research Institute (SK)
- Christian Doppler Laboratory for Thermoelectricity (AT)
- Ultrasonic Technologies (United States) (US)
- Zhejiang University (CN)
Publication Details
- Journal
- ACS Omega
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1021/acsomega.5c13226
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Zhejiang University