Alkaloids from In Vitro Cultured Rhodophiala pratensis Display Neuroprotective Effects in Murine Microglial Cell Models of Inflammation
. Homolycorine-type, norbelladine-type and crinine-type alkaloids produced in vitro reduced LPS-induced inflammation (5 µg/mL), possibly via α7 and α4β2 nAChRs, and showed a protective effect against OHDA-induced oxidative stress (1-3 µg/mL) and inhibited AChE and BuChE (24-78 µg/mL).
Authors
- Edgar Pastene (ORCID: https://orcid.org/0000-0001-5437-9210)
- Julio Alarcón (ORCID: https://orcid.org/0000-0001-7473-8823)
- Luís Bustamante (ORCID: https://orcid.org/0000-0001-5077-474X)
- Manuela García López
- Diana Correa-Otero
- Ángela Gómez-Mediavilla
- Nandis Fiallos
- Carlota Siguero-Gómez (ORCID: https://orcid.org/0009-0003-0896-5819)
Institutions
- University of Concepción (CL)
- San Sebastián University (CL)
- University of Bío-Bío (CL)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Plants
- Published
- 2026-04-12
- DOI
- https://doi.org/10.3390/plants15081186
- Primary Topic
- Chemical synthesis and alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Universidad del Bío-Bío
- Agencia Nacional de Investigación y Desarrollo
- Comisión Nacional de Investigación Científica y Tecnológica