The DBC1-HIF-1α-PPAR-γ axis regulates Treg cell differentiation to promote myocardial fibrosis in experimental diabetic cardiomyopathy through the paracrine secretion of Areg

Background: Regulatory T (Treg) cells play crucial roles in myocardial fibrosis, a key pathological feature of diabetic cardiomyopathy (DCM). Deleted in breast cancer 1 (DBC1) has emerged as an inhibitor of the immunosuppressive function of Treg cells in inflammatory states. Here, we studied the subpopulation differentiation and function of Treg cells in the myocardium of DCM and explored the role of DBC1 in Treg cell differentiation. Methods: Treg cells on fibroblast behaviors. Results: subgroup in DCM through the HIF-1α-PPAR-γ axis. Conclusion: pro-fibrotic subgroup, which drives maladaptive myocardial fibrosis and cardiac dysfunction via paracrine secretion of Areg in DCM mice.