Different Metabolic Responses to Long-term Weight Loss After Lifestyle Intervention Among Type 2 Diabetes Risk Clusters: Results From the TULIP Study
ARTICLE HIGHLIGHTS: There may be heterogeneity in the response to a lifestyle intervention to prevent type 2 diabetes. This study investigated whether participants of Tübingen Lifestyle Intervention Program (TULIP) type 2 diabetes risk clusters 3 and 5, who have a very high risk of diabetes, benefit from long-term weight loss following a 2-year lifestyle intervention. Diabetes risk cluster 5 participants had an impaired response regarding improvement of glycemia and insulin secretion and a high risk of developing type 2 diabetes, despite a long-term (9-year) mean weight loss of 8%. Alternative or intensified interventions should be considered for people in Tübingen type 2 diabetes risk cluster 5.
Authors
- Norbert Stefan (ORCID: https://orcid.org/0000-0002-2186-9595)
- Martin Heni (ORCID: https://orcid.org/0000-0002-8462-3832)
- Marlene Ganslmeier
- Fritz Schick (ORCID: https://orcid.org/0000-0002-4231-3406)
- K Kantartzis
- Andreas Fritsche (ORCID: https://orcid.org/0000-0002-4987-1961)
- Reiner Jumpertz von Schwartzenberg (ORCID: https://orcid.org/0000-0002-5544-099X)
- AL Birkenfeld
- Caroline Meier
- Andreas Peter
- Hans-Ulrich Häring
- Robert Wagner
- Jürgen Machann
Institutions
- Düsseldorf University Hospital (DE)
- University Children's Hospital Tübingen (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- University Hospital Ulm (DE)
- German Center for Diabetes Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Diabetes
- Published
- 2026-04-13
- DOI
- https://doi.org/10.2337/db25-0757
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Deutsches Zentrum für Diabetesforschung