Assessment of the modified glasgow prognostic scale and inflammatory parameters as a new prognostic indicator in pulmonary thromboembolism patients

Acute Pulmonary Embolism (PE) is a common and life-threatening condition, necessitating early prognostic evaluation. While various prognostic scoring systems exist, most lack parameters reflecting the inflammatory aspect of PE. This study aimed to assess the prognostic significance of inflammatory markers, particularly the modified Glasgow Prognostic Scale (mGPS), and their relationship with established prognostic tools like the Pulmonary Embolism Severity Index (PESI). We retrospectively analyzed 436 patients diagnosed with acute PE and hospitalized in the Department of Chest Diseases at Dicle University Medical Faculty between January 2020 and January 2024. Patients with incomplete records were excluded, leaving 334 for final analysis. mGPS scores were calculated and categorized as 0, 1, or 2. We examined associations between mGPS scores, PESI, 30-day and 90-day mortality, and other inflammatory parameters. The mean age of the cohort was 61.52 ± 17.12 years. Patients with an mGPS score of 2 had significantly higher PESI scores (p < 0.001) and increased 30-day and 90-day mortality rates (p < 0.001). A strong, positive correlation was observed between mGPS and PESI (r = 0.536, p < 0.001). ROC analysis identified albumin (AUC: 0.878) and oxygen saturation (AUC: 0.854) as the best-performing predictors for PESI classification. A predictive model combining mGPS, oxygen saturation, and systolic blood pressure outperformed sPESI in mortality prediction (AUC: 0.748, cut-off: 2.5). The mGPS score is a significant prognostic marker for 30- and 90-day mortality in PE patients and outperforms sPESI in predicting PESI scores. Our simplified model incorporating mGPS, oxygen saturation, and systolic blood pressure provides a practical and effective alternative to existing tools for prognostic evaluation in acute PE.