Bimetallic Silver–Gold Nanoplates for Photothermal Antimicrobial Therapy: Integrating High Efficiency with Stable and Multifunctional Design

. Systematic evaluation showed that thiol-terminated polyethylene glycol functionalization preserves the optical response of the nanoplates while improving colloidal stability in biologically relevant media. Furthermore, we investigated the trade-off between multifunctionality, stability, and photothermal efficiency observed after silica coating followed by covalent BSA conjugation, which increases surface functionalization versatility but reduces antimicrobial performance under the tested conditions. This work presents an efficient route to synthesize bimetallic Ag-Au nanoplates in large-volume batch for noninvasive antimicrobial photothermal applications and outlines key design principles to guide the development of next-generation multifunctional plasmonic nanoplatforms for antimicrobial therapy.

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Publication Details

Journal
ACS Applied Nano Materials
Published
2026-04-13
DOI
https://doi.org/10.1021/acsanm.6c00304
Primary Topic
Gold and Silver Nanoparticles Synthesis and Applications
Type
article
Field-Weighted Citation Impact
0.00

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article

Bimetallic Silver–Gold Nanoplates for Photothermal Antimicrobial Therapy: Integrating High Efficiency with Stable and Multifunctional Design

Fernando Novio, Sebastián Tanco, Júlia Lorenzo, Carlos Lodeiro et al.
ACS Applied Nano Materials
Gold and Silver Nanoparticles Synthesis and Applications
article

Bimetallic Silver–Gold Nanoplates for Photothermal Antimicrobial Therapy: Integrating High Efficiency with Stable and Multifunctional Design

Fernando Novio, Sebastián Tanco, Júlia Lorenzo, Carlos Lodeiro, Javier Fernández‐Lodeiro
article en

Abstract

. Systematic evaluation showed that thiol-terminated polyethylene glycol functionalization preserves the optical response of the nanoplates while improving colloidal stability in biologically relevant media. Furthermore, we investigated the trade-off between multifunctionality, stability, and photothermal efficiency observed after silica coating followed by covalent BSA conjugation, which increases surface functionalization versatility but reduces antimicrobial performance under the tested conditions. This work presents an efficient route to synthesize bimetallic Ag-Au nanoplates in large-volume batch for noninvasive antimicrobial photothermal applications and outlines key design principles to guide the development of next-generation multifunctional plasmonic nanoplatforms for antimicrobial therapy.

ACS Applied Nano MaterialsVol. 9(16)
Universitat Autònoma de Barcelona (ES), Instituto de Salud Carlos III (ES), Protein Society (US), Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES), Scope Group (United States) (US), Universidade Nova de Lisboa (PT)
Ministerio de Ciencia, Innovación y Universidades, Ministério da Ciência, Tecnologia e Ensino Superior, Proteomass Scientific Society, Fundação para a Ciência e a Tecnologia, European Regional Development Fund, NextGenerationEU
Openalex Percentile: Top 25%
Gold and Silver Nanoparticles Synthesis and Applications
DOIOpen Access PDFOpenAlex
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