Experimental Diabetic Retinopathy in Wistar Rats Induced by Streptozotocin: A Window into Retinal Disease Progression
T cells suggested transient immune activation during STZ-induced retinal degeneration. Gene expression profiling revealed a proinflammatory and pro-oxidative retinal microenvironment, characterized by the overexpression of angiogenic pathways and proliferative signals. Simultaneously, the antioxidant response appeared partially impaired. Collectively, these findings provide mechanistic perspective on the multifactorial nature of diabetic retinopathy. Oxidative stress, inflammation, and angiogenesis converge to disrupt retinal homeostasis. This experimental model may serve as a reliable platform for future studies aimed at elucidating disease pathophysiology, identifying novel therapeutic targets, and evaluating emerging ophthalmic antidiabetic interventions.
Authors
- Javier Ventura‐Juárez (ORCID: https://orcid.org/0000-0002-3083-0131)
- Luis Fernando Barba-Gallardo (ORCID: https://orcid.org/0000-0002-1514-8230)
- Luis Héctor Salas-Hernández
- Paloma Lucía Guerra-Ávila (ORCID: https://orcid.org/0000-0002-5139-0235)
- Martín Humberto Muñoz‐Ortega (ORCID: https://orcid.org/0000-0002-1961-6919)
- Manuel Enrique Ávila‐Blanco (ORCID: https://orcid.org/0000-0003-3180-2471)
- Elizabeth Casillas-Casillas
- Ruth Clarisa Murillo-Ruíz
- José Luis Díaz-Rubio
- Marcela Rivera-Delgadillo (ORCID: https://orcid.org/0009-0002-0402-8716)
Institutions
- Autonomous University of Aguascalientes (MX)
- Universidad Tecnológica de Aguascalientes (MX)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2026-04-11
- DOI
- https://doi.org/10.3390/ijms27083427
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad Autónoma de Aguascalientes