ARID1A deficiency unleashes centromeric RNA transcription to drive chromosomal instability and boosts PKMYT1 inhibitor efficacy via RNA sensing
deficiency unleashes centromeric α-SatRNA transcription, which sets the molecular stage for tumor evolution and targeted therapy by coordinately inducing CIN and self-dsRNA-induced innate immune responses.
Authors
- Gengyi Zou (ORCID: https://orcid.org/0000-0002-5399-8674)
- Liyong Zeng
- C. Li
- Rugang Zhang (ORCID: https://orcid.org/0000-0002-7255-2360)
- Yibo Fan (ORCID: https://orcid.org/0000-0003-2523-8261)
- Guang Peng (ORCID: https://orcid.org/0009-0004-4756-8872)
- Yuan‐Hung Lo (ORCID: https://orcid.org/0000-0002-9704-3124)
- Guocan Wang
- Shumei Song
- Thi Hong Minh Nguyen
- Jaffer Ajani
- Ming Zhao
- Timothy A. Yap
- Emily Zhao
- Xueqian Cheng
- Wiezhen Liu
- Shilpa Dhar
- Noemi Ira
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Coriell Institute For Medical Research (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-13
- DOI
- https://doi.org/10.64898/2026.04.11.717899
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense