Dynamic Evolution of Fe <sub>3</sub> O <sub>4</sub> Nanoparticles’ Protein Corona during Extracellular to Intracellular Trafficking: The Interference of Integrin αMβ2
internalization. Furthermore, we emphasize the active role of the cell membrane in protein corona remodeling, with high-abundance fibrinogen being retained at the cell membrane through receptor regulation. These findings uncover a critical, previously overlooked dimension of protein-corona biology: the intracellular fate of plasma proteins dictates NPs' trafficking and toxicities, thereby linking environmental exposure to human health risk.
Authors
- Tianlei Sun (ORCID: https://orcid.org/0009-0008-3342-296X)
- Xuting Liu (ORCID: https://orcid.org/0000-0003-3980-5386)
- Xiangyu Zhu (ORCID: https://orcid.org/0000-0002-4636-9677)
- J. C. CAO
- Guibin Jiang (ORCID: https://orcid.org/0000-0002-6335-3917)
Institutions
- Chinese Academy of Sciences (CN)
- Institute for Advanced Study (DE)
- Research Center for Eco-Environmental Sciences (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Environmental Science & Technology
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1021/acs.est.6c01494
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- National Key Research and Development Program of China