Geographical variability in severe asthma: comparison of patients’ characteristics between national, regional, and international cohorts in ISAR
OBJECTIVE: The objective of this study is to describe and compare the clinical characteristics, treatment approaches, and associated comorbidities of patients with severe asthma across Greece, Southern Europe, and the global population. This comparative approach aims to enhance the understanding of region-specific differences and similarities among patients living with severe asthma. METHODS: Data from the International Severe Asthma Registry (ISAR) were analyzed across three cohorts: Greek, Southern European, and Global. Variables included demographics, baseline characteristics, age at asthma onset, medication use, lung function, exacerbation history, biomarkers, and comorbidities. RESULTS: = 0.024). CONCLUSIONS: Regional differences in severe asthma underline the importance of tailored treatment approaches, and multidisciplinary management of comorbid conditions.
Authors
- Maria Ntakoula
- S Loukides
- Andriana Ι. Papaioannou (ORCID: https://orcid.org/0000-0001-9708-3241)
- P Bakakos
- Giannis Paraskevopoulos
- Konstantinos Exarchos (ORCID: https://orcid.org/0000-0002-4754-7623)
- B G Cosío
- Athena Gogali (ORCID: https://orcid.org/0000-0002-4321-9446)
- Konstantinos Tatsis (ORCID: https://orcid.org/0000-0002-5984-3649)
- Εleftherios Ζervas (ORCID: https://orcid.org/0000-0001-7436-4550)
- Mina Gaga (ORCID: https://orcid.org/0000-0002-9949-6012)
- Ghislaine Scélo (ORCID: https://orcid.org/0000-0002-2692-8507)
- Lampros A. Kalogiros
- Maria Kallieri (ORCID: https://orcid.org/0000-0002-4282-4249)
- Nuria Marina Malanda
- Aggelos Ladias
- M. Makris
- Aaron Beastall
- Giorgio Walter Canonica
- Enrico Heffler
- David B. Price
- João A. Fonseca
- Victoria Carter
- Fotios E. Psarros
- Konstantinos Kostikas
- Dominic A. Friston
- Nikolaos G Papadopoulos
Institutions
- Humanitas University (IT)
- Universidade do Porto (PT)
- University of Ioannina (GR)
- University of Aberdeen (GB)
- National and Kapodistrian University of Athens (GR)
- Military Hospital (PK)
- BioCruces Health research Institute (ES)
- Chest Diseases Hospital (KW)
- Observational & Pragmatic Research Institute (SG)
- Hygeia Hospital (GR)
- Primary Health Care (QA)
- Centre for Health Technology and Services Research (PT)
- University General Hospital Attikon (GR)
- Hospital Universitario Son Espases (ES)
- IRCCS Humanitas Research Hospital (IT)
- Sotiria General Hospital (GR)
Publication Details
- Journal
- Journal of Asthma
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1080/02770903.2026.2654601
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca