Long-term HIV-1 remission achieved through allogeneic haematopoietic stem cell transplant from a CCR5Δ32/Δ32 sibling donor
Only few cases of human immunodeficiency virus (HIV) remission have been reported after allogeneic haematopoietic stem cell transplantation (HSCT), mostly involving stem cell donors with the homozygous CCR5Δ32 (CCR5Δ32/Δ32) mutation, which confers resistance to CCR5-tropic HIV-1. Here we report the case of a 63-year-old man in off-treatment HIV remission, 5 years after HSCT with a CCR5Δ32/Δ32 sibling donor for myelodysplastic syndrome. In-depth clinical characterization including virological and immunological analyses of peripheral blood, gut and bone marrow samples revealed that full donor chimerism was achieved. Antiretroviral therapy was discontinued after 24 months, and 48 months after HSCT, no intact HIV DNA was detected in blood or gut biopsies. Replication-competent virus and HIV-specific T cell responses were absent, and HIV antibody responses showed a gradual decline. Full donor chimerism in the gut, which is the primary viral reservoir, underscores the likelihood of a cure.
Authors
- Mona Holberg‐Petersen (ORCID: https://orcid.org/0000-0002-3490-680X)
- Victoria González Soler
- Gunilla Løvgården
- Mari Kaarbø (ORCID: https://orcid.org/0000-0003-3983-6545)
- Magnar Bjørås (ORCID: https://orcid.org/0000-0001-8759-1170)
- Jagjit Singh Bhamra (ORCID: https://orcid.org/0000-0002-8423-8440)
- Dag Henrik Reikvam (ORCID: https://orcid.org/0000-0002-4499-0320)
- Anne‐Marte Bakken Kran (ORCID: https://orcid.org/0000-0003-3056-9137)
- Bente Lise Halvorsen (ORCID: https://orcid.org/0000-0002-6529-6485)
- Andreas Lind (ORCID: https://orcid.org/0000-0002-8289-8410)
- M. Salgado
- Katie Fisher (ORCID: https://orcid.org/0000-0002-8732-706X)
- Mariane Høgsbjerg Schleimann (ORCID: https://orcid.org/0000-0001-5147-9523)
- T. Gedde-Dahl
- Ole S. Søgaard (ORCID: https://orcid.org/0000-0001-9107-2023)
- Frode L. Jahnsen (ORCID: https://orcid.org/0000-0003-3843-7171)
- Malin Holm Meyer‐Myklestad (ORCID: https://orcid.org/0000-0003-3162-5196)
- Jesper Damsgaard Gunst (ORCID: https://orcid.org/0000-0002-3787-0259)
- Hans Christian D. Aass (ORCID: https://orcid.org/0000-0002-0395-047X)
- Gema Fernández Rivas
- Javier Martínez‐Picado (ORCID: https://orcid.org/0000-0002-4916-2129)
- Marius Trøseid (ORCID: https://orcid.org/0000-0001-7775-3404)
- Azita Rashidi
- Hanne Guldsten
- Tuva Børresdatter Dahl (ORCID: https://orcid.org/0000-0001-7818-9411)
- Irene González Navarro
- Anna Karina Juhl (ORCID: https://orcid.org/0000-0001-6079-5173)
- Astrid Thomsen
- Fredrik Müller (ORCID: https://orcid.org/0000-0003-0812-0640)
- Magnus Moksnes
- Águeda Hernández
- Anders Eivind Myhre
- Asle W Medhus
- Anne Ma Dyrhol-Riise
- Marte L. Høivik
- Oslo HIV Cure Study Group
- Pål Aukrust
- Anders Sönnerborg
- Martin Tolstrup
- Maria del Carmen García Guerrero
- Gerard Campos
- Piotr Nowak
- Anne Marte Bakken-Kran
- Anders E. Myhre
- Sarah Nur
- Jagiit S. Bhamra
- Hanne Hestdal Gullaksen (ORCID: https://orcid.org/0009-0007-1177-4262)
Institutions
- Universitat de Vic - Universitat Central de Catalunya (ES)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Oslo University Hospital (NO)
- Norwegian Institute of Public Health (NO)
- University of Oslo (NO)
- Aarhus University (DK)
- Instituto de Salud Carlos III (ES)
- Sykehuset i Vestfold (NO)
- Aarhus University Hospital (DK)
- Karolinska Institutet (SE)
- IrsiCaixa (ES)
- Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES)
Publication Details
- Journal
- Nature Microbiology
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1038/s41564-026-02304-8
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Aarhus Universitet
- Fundació la Marató de TV3
- Centres de Recerca de Catalunya
- European Commission
- Lundbeckfonden
- Novo Nordisk
- Danmarks Frie Forskningsfond
- Ministerio de Ciencia e Innovación
- H. Lundbeck A/S
- Grifols
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases