Effect of vitamin D supplementation on blood lipids in patients with metabolic syndrome: a meta-analysis

Background: Vitamin D, a fat-soluble vitamin critical for bone metabolism, has recently been implicated in metabolic homeostasis. Growing evidence suggests its potential role in modulating lipid profiles in metabolic syndrome. Objectives: This meta-analysis evaluated the effects of vitamin D supplementation on blood lipids in patients with metabolic syndrome. Methods: We searched the randomized controlled trials from 1948 to February 1, 2026 involving vitamin D supplementation treatment for patients with metabolic syndrome from PubMed, EMBASE, Cochrane library, SinoMed, and conducted a meta-analysis. The meta-analysis was registered on the PROSPERO, the registration number is CRD42024591657. Results: = 35%). Conclusions: Our meta-analysis confirmed the effects of vitamin D in the management of triglyceride level in metabolic syndrome patients. Vitamin D supplementation showed potential benefits on increasing the high-density lipoprotein cholesterol levels especially with daily regimens. More randomized controlled trials are needed to confirm the result.