Analysis of the expression of FAP, Caveolin1, and CPXM2 and prognostic significance in gastric cancer

Background: This study sought to examine the expression levels and clinical relevance of fibroblast activation protein alpha (FAP), caveolin-1 (CAV1), and carboxypeptidase X member 2 (CPXM2) in gastric cancer (GC) and adjacent tissues. Methods: Multiplex immunofluorescence (mIF) was performed on tissue microarrays to evaluate the expression of FAP, CAV1, CPXM2, and cytokeratin (CK) in GC specimens. Correlations among these markers and their associations with clinicopathological features and survival outcomes were analyzed. Results: cells were associated with poorer overall survival (OS). Conclusions: These findings suggest that CAV1 and CPXM2 are differentially expressed in GC and associated with patient prognosis, highlighting them as potential candidates for further functional investigation in the context of GC progression.