PD-1 high expression in T lymphocytes correlates with decreased survival in childhood B-cell precursor acute lymphoblastic leukemia
. Furthermore, it demonstrated a correlation between high PD-1 expression on CD4 and CD8 T lymphocytes and survival in pediatric BCP-ALL. These results suggest that PD-1 may serve as a prognostic biomarker and a potential target for immune-based therapeutic strategies in BCP-ALL.
Authors
- Clara de Oliveira Andrade (ORCID: https://orcid.org/0009-0000-9925-6134)
- Eugênia Terra‐Granado (ORCID: https://orcid.org/0000-0002-3616-140X)
- Daniella Arêas Mendes‐da‐Cruz (ORCID: https://orcid.org/0000-0003-3697-1506)
- Elda Pereira Noronha (ORCID: https://orcid.org/0000-0001-5381-9544)
- Maria S. Pombo‐de‐Oliveira (ORCID: https://orcid.org/0000-0002-1507-004X)
- Teresa de Souza Fernandez (ORCID: https://orcid.org/0000-0003-1299-4666)
- José Carlos Aragão-Santos
- Chaislan Igor da Silva Nascimento
Institutions
- Universidade Estadual de Santa Cruz (BR)
- Instituto Nacional de Câncer - INCA (BR)
- Universidade Estadual do Maranhão (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Human Immunology
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1016/j.humimm.2026.111740
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Swiss Bridge Foundation
- Instituto Nacional do Câncer, Ministério da Saúde