Saikosaponin D Alleviates Liver Ischemia–Reperfusion Injury by Inhibiting Mitophagy‐Associated Ferroptosis via the <scp>STAT3</scp> / <scp>PINK1</scp> Pathway
accumulation, lipid peroxidation and malondialdehyde levels, accelerated GSH depletion, aggravated the downregulation of Glutathione Peroxidase 4 (GPX4) and Solute carrier family 7 membrane 11 (SLC7A11) and upregulation of Transferrin receptor (TFR), while PINK1 silencing produced similar results. The inhibitory effect of SSD on ferroptosis in a hypoxia-reoxygenation model was counteracted by STAT3 overexpression and PINK1 silencing. SSD protects the liver against ischemia-reperfusion injury by inhibiting ferroptosis through STAT3/PINK1/PARKIN-mediated mitophagy, highlighting its potential as a therapeutic agent in liver ischemia-reperfusion injury treatment.
Authors
- Xiaolan Yu (ORCID: https://orcid.org/0000-0003-1588-9693)
- Haijian Cai
- Jing Du (ORCID: https://orcid.org/0009-0001-7172-1089)
- Yaru Xu
- Youwen Han
- Xingyun Liu
- Xiao Feng
- Lijian Chen
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Phytotherapy Research
- Published
- 2026-04-12
- DOI
- https://doi.org/10.1002/ptr.70333
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China